Dr. Crusher Visits NASA
NASA
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Brojakowska A, Kour A, Thel MC, Park E, Bisserier M, Garikipati VNS, Hadri L, Mills PJ, Walsh K, Goukassian DA.
Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts.
Commun Biol. 2022 Aug 17;5:828.
https://pubmed.ncbi.nlm.nih.gov/35978153
PIs: K. Walsh, D.A. Goukassian
Note: From the abstract: “With planned deep space and commercial spaceflights, gaps remain to address health risks in astronauts. Multiple studies have shown associations between clonal expansion of hematopoietic cells with hematopoietic malignancies and cardiometabolic disease. This expansion of clones in the absence of overt hematopoietic disorders is termed clonal hematopoiesis (CH) of indeterminate potential (CHIP). Using deep, error-corrected, targeted DNA sequencing we assayed for somatic mutations in CH-driver genes in peripheral blood mononuclear cells isolated from de-identified blood samples collected from 14 astronauts who flew Shuttle missions between 1998-2001.”
Journal Impact Factor: 6.548
Funding: “We would like to thank the Lifetime Surveillance of Astronaut Health (LSAH) at NASA Johnson Space Center for their assistance with mission information and manuscript review. This work was supported by the Translational Research Institute for Space Health award FIP0005 (to Dr. Goukassian), National Aeronautics and Space Administration Human Research Program Space Biology Element grant 80NSSC19K1079 (to Dr. Goukassian), and National Aeronautics and Space Administration Human Research Program Space Biology Element grant 80NSSC21K0549 (to Drs. Goukassian and Walsh).”
2
Buettmann EG, Goldscheitter GM, Hoppock GA, Friedman MA, Suva LJ, Donahue HJ.
Similarities between disuse and age‐induced bone loss.
J Bone Miner Res. 2022 Aug;37(8):1417-34. Review.
https://pubmed.ncbi.nlm.nih.gov/35773785
PIs: E.G. Buettmann, M.A. Friedman, H.J. Donahue
Journal Impact Factor: 6.390
Funding: “EGB and MAF were supported by the Translational Research Institute for Space Health through Cooperative Agreement with NASA (NNX16AO69A). HJD, GMG, and GAH were supported by NIH (NIAMS) grant R01 (AR068132), NASA grant 80NSSC18K1473, and National Space Biological Research Institute grant NSBRI/NASA, (MA02802). LJS is supported by R01HD102909 and 4R37 AA018282 from NIH.”
3
Omer M, Ali H, Orlovskaya N, Ballesteros A, Cheong VS, Martyniak K, Wei F, Collins BE, Yarmolenko SN, Asiatico J, Kinzel M, Ngo C, Sankar J, Calder A, Gilbertson T, Meckmongkol T, Ghosh R, Coathup M.
Omega-9 modifies viscoelasticity and augments bone strength and architecture in a high-fat diet-fed murine model.
Nutrients. 2022 Jul 31;14(15):3165.
https://pubmed.ncbi.nlm.nih.gov/35956341
Note: This article is part of Section “Lipids” (https://www.mdpi.com/journal/nutrients/sections/Lipids) and may be obtained online without charge.
Journal Impact Factor: 6.706
Funding: “This study was internally funded. Authors JA and CN’s work was supported by the National Aeronautics and Space Administration [grant No. 80NSSC21M0309] issued through the NASA Office of STEM Engagement.”
4
Stone KA, Mahoney SJ, Paryzek RA, Pitts L, Stastny SN, Mitchell SL, Downs ME, English KL, Hackney KJ.
Intermittent blood flow restriction exercise rapidly improves muscular and cardiovascular health in adults with beyond adequate protein intakes.
Acta Astronaut. 2022 Oct;199:224-31.
https://doi.org/10.1016/j.actaastro.2022.07.050
Note: From the abstract: “Functional losses associated with spaceflight negatively influence astronaut health and mission success. Exercise combined with protein supplementation is a promising countermeasure. Blood flow restricted (BFR) exercise is an effective modality, but synergistic benefits when combined with protein supplementation are not clearly identified. The purposes of this investigation were to determine if blended (e.g., whey and casein) protein supplementation combined with BFR exercise favorably altered body composition, muscle function, and cardiovascular health during a short training program.”
Journal Impact Factor: 2.954
Funding: M. Everett is affiliated with NASA Johnson Space Center.
5
Smith KJ, Datta A, Burkhart C, Clark TK.
Efficacy of galvanic vestibular stimulation as a display modality dissociated from self-orientation.
Hum Factors. 2022 Aug 16;187208221119879. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35971664
Journal Impact Factor: 3.598
Funding: C. Burkhart is affiliated with NASA Johnson Space Center.
6
Wang M, Yang Y, Min J, Song Y, Tu J, Mukasa D, Ye C, Xu C, Heflin N, McCune JS, Hsiai TK, Li Z, Gao W.
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients.
Nat Biomed Eng. 2022 Aug 15.
https://pubmed.ncbi.nlm.nih.gov/35970928
PI: W. Gao
Note: From the abstract: “Wearable non-invasive biosensors for the continuous monitoring of metabolites in sweat can detect a few analytes at sufficiently high concentrations, typically during vigorous exercise so as to generate sufficient quantity of the biofluid. Here, we report the design and performance of a wearable electrochemical biosensor for the continuous analysis, in sweat during physical exercise and at rest, of trace levels of multiple metabolites and nutrients, including all essential amino acids and vitamins.” This article may be obtained online without charge.
Journal Impact Factor: 29.234
Funding: “This project was supported by the National Institutes of Health grant R01HL155815, Office of Naval Research grants N00014-21-1-2483 and N00014-21-1-2845, the Translational Research Institute for Space Health through NASA NNX16AO69A, NASA Cooperative Agreement 80NSSC20M0167, High Impact Pilot Research Award T31IP1666 and grant R01RG3746 from the Tobacco-Related Disease Research Program, Caltech-City of Hope Biomedical Initiative Pilot Grant and the Rothenberg Innovation Initiative Program at California Institute of Technology. J.T. was supported by the National Science Scholarship (NSS) from the Agency of Science Technology and Research (A*STAR) Singapore.”
7
Weber Boutros S, Unni VK, Raber J.
An adaptive role for DNA double-strand breaks in hippocampus-dependent learning and memory.
Int J Mol Sci. 2022 Jul 28;23(15):8352. Review.
https://pubmed.ncbi.nlm.nih.gov/35955487
PI: J. Raber/NSCOR
Note: This article is part of Research Topic “Molecular and Cellular Mechanisms of Brain Disease: Hippocampus as a Nodal Point” (https://www.mdpi.com/journal/ijms/special_issues/Hippocampus). This article may be obtained online without charge.
Journal Impact Factor: 6.208
Funding: “This work was partially funded by a NSF Graduate Research Fellowship award, NASA NSCOR G-00066-4, R21 CA223461, R21 AG065914, RF1 AG059088, P30 AG066509, NS102227, F31 AG067629, Knight CVP-003, and the development accounts of Unni and Raber.”
___________________________________________________
Other papers of interest:
1
Belavy DL, Armbrecht G, Albracht K, Brisby H, Falla D, Scheuring R, Sovelius R, Wilke HJ, Rennerfelt K, Martinez-Valdes E, Arvanitidis M, Goell F, Braunstein B, Kaczorowski S, Karner V, Arora NK.
Cervical spine and muscle adaptation after spaceflight and relationship to herniation risk: Protocol from ‘Cervical in Space’ trial.
BMC Musculoskelet Disord. 2022 Aug 13;23:772.
https://pubmed.ncbi.nlm.nih.gov/35964076
Note: ISS results. This article may be obtained online without charge.
2
Baran R, Wehland M, Schulz H, Heer M, Infanger M, Grimm D.
Microgravity-related changes in bone density and treatment options: A systematic review.
Int J Mol Sci. 2022 Aug 3;23(15):8650. Review.
https://pubmed.ncbi.nlm.nih.gov/35955775
Note: This article and the article below (Lichterfeld et al.) are part of Topic “Translation from Microgravity Research to Earth Application” (https://www.mdpi.com/topics/microgravity_research). The Topic also includes articles from previous Current Awareness Lists #970 https://doi.org/10.3390/ijms22189997 and https://doi.org/10.3390/biomedicines9091205; #976 https://doi.org/10.3390/ijms222111759; #984 https://doi.org/10.3390/biomedicines10010059; and #989 https://doi.org/10.3390/biomedicines10020448. This article may be obtained online without charge.
3
Lichterfeld Y, Kalinski L, Schunk S, Schmakeit T, Feles S, Frett T, Herrmann H, Hemmersbach R, Liemersdorf C.
Hypergravity attenuates reactivity in primary murine astrocytes.
Biomedicines. 2022 Aug 13;10(8):1966.
https://doi.org/10.3390/biomedicines10081966
Note: From the abstract: “Neuronal activity is the key modulator of nearly every aspect of behavior, affecting cognition, learning, and memory as well as motion. Hence, disturbances of the transmission of synaptic signals are the main cause of many neurological disorders. Lesions to nervous tissues are associated with phenotypic changes mediated by astrocytes becoming reactive. Reactive astrocytes form the basis of astrogliosis and glial scar formation. Astrocyte reactivity is often targeted to inhibit axon dystrophy and thus promote neuronal regeneration. Here, we aim to understand the impact of gravitational loading induced by hypergravity to potentially modify key features of astrocyte reactivity. We exposed primary murine astrocytes as a model system closely resembling the in vivo reactivity phenotype on custom-built centrifuges for cultivation as well as for live-cell imaging under hypergravity conditions in a physiological range (2g and 10g).” This article and the article above (Baran et al.) are part of Topic “Translation from Microgravity Research to Earth Application” (https://www.mdpi.com/topics/microgravity_research). This article may be obtained online without charge.
4
Ibrahim Z, Ramachandran G, El-Huneidi W, Elmoselhi A, Qaisar R.
Suppression of endoplasmic reticulum stress prevents disuse muscle atrophy in a mouse model of microgravity.
Life Sci Space Res (Amst). 2022 Aug;34:45-52.
https://pubmed.ncbi.nlm.nih.gov/35940689
Note: From the abstract: “Hindlimb unloaded (HLU) mouse model exhibits skeletal muscle atrophy and weakness mimicking the conditions such as prolonged spaceflight. However, the molecular mechanisms and interventions of muscle loss during muscle unloading remain elusive. Dysfunction of protein folding by ednoplasmic reticulum (ER), a condition called ER stress, is implicated in diseases of various cell types, but its contribution to skeletal muscle detriment remains elusive. In this study, we investigated the contribution of ER stress to muscle atrophy.”
5
Naito M, Kodaira S.
Considerations for practical dose equivalent assessment of space radiation and exposure risk reduction in deep space.
Sci Rep. 2022 Aug 10;12:13617.
https://pubmed.ncbi.nlm.nih.gov/35948565
Note: This article may be obtained online without charge.
6
Coulombe JV, Harrisson G, Lewis BJ, El-Jaby S.
Evolving radiological protection guidelines for exploration-class missions.
Life Sci Space Res. 2022 Aug 13. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.08.004
Note: From the abstract: “International Space Station partner nations have yet to agree on career radiation dose constraints. This is of increasing concern for collaborative mission planning beyond low-Earth orbit, since it is likely that one or two long-duration missions will expose crew to a cumulative dose that approaches or exceeds their current respective limits. As with radiological effects, the cumulative health impact of the numerous other injuries and illnesses documented during spaceflight is inherently heightened with longer and farther missions, say to the Moon and Mars. This paper summarizes the origin of existing radiological constraints employed by the Canadian Space Agency and explores how to build upon these protection practices to address the challenges associated with beyond low-Earth orbit missions.”
7
Nakamura JL.
Considerations for carcinogenesis countermeasure development using mouse models.
Life Sci Space Res. 2022 Aug 12. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.08.005
Note: From the abstract: “Activities in space will expose humans to profoundly new environments, challenging human performance and will require innovative supportive technologies. Among these environmental variables, exposure to ionizing radiation is a major concern for astronauts, as the long-term effects of exposure on diverse tissues are poorly understood. This need however creates opportunities for novel approaches, particularly in the development of countermeasures against the effects of ionizing radiation exposure. Carcinogenesis presents a unique challenge as a disease process, due to the inherent complexities of the process and the challenges of obtaining a large volume of clinical evidence. Thus, developing the countermeasures to address potential effects of ionizing radiation exposure will require understanding biological underpinnings to design countermeasures effectively in conjunction with highly robust modeling approaches to test and examine in vivo. This review will highlight specific considerations for accelerated development of space radiation countermeasures against carcinogenesis.”
8
Liu H, Li BW, Chen J, Shen Z, Zhang X, Wang J, Nan CW.
Concurrent enhancement of breakdown strength and dielectric constant in poly(vinylidene fluoride) film with high energy storage density by ultraviolet irradiation.
ACS Omega. 2022 Jul 22;7(30):25999-6004.
https://pubmed.ncbi.nlm.nih.gov/35936448
Note: This article may be obtained online without charge.
9
Frett T, Lecheler L, Speer M, Marcos D, Pesta D, Tegtbur U, Schmitz M-T, Jordan J, Green DA.
Comparison of trunk muscle exercises in supine position during short arm centrifugation with 1 g at centre of mass and upright in 1 g.
Front Physiol. 2022 Aug 17;13:955312.
https://doi.org/10.3389/fphys.2022.955312
Note: Short-arm human centrifuge results. This article may be obtained online without charge.
10
Eimantas N, Ivanove S, Baranauskiene N, Solianik R, Brazaitis M.
Modulation of neuromuscular excitability in response to acute noxious heat exposure has no additional effects on central and peripheral fatigability.
Front Physiol. 2022 Aug 12;13:936885.
https://doi.org/10.3389/fphys.2022.936885
Note: From the abstract: “Whole-body hyperthermia (WBH) has an adverse effect on the nervous system and neurophysiological performance. In the present study, we examined whether short-duration whole-body immersion in 45°C water (HWI-45°C), which produces a strong neural and temperature flux without inducing WBH, can increase or impair neurophysiological performance in humans.” This article may be obtained online without charge.
11
Chen X, Tang K, Li X, Zhang C, Xin Y, Li K, Tan Y.
Biomechanics of cancer stem cells.
Essays Biochem. 2022 Aug 9;EBC20220014. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35942932
12
Ruotsalainen SE, Surakka I, Mars N, Karjalainen J, Kurki M, Kanai M, Krebs K, Graham S, Mishra PP, Mishra BH, Sinisalo J, Palta P, Lehtimäki T, Raitakari O, Milani L, Okada Y, Palotie A, Widen E, Daly MJ, Ripatti S.
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis.
Commun Biol. 2022 Aug 17;5:802.
https://pubmed.ncbi.nlm.nih.gov/35978133
Note: From the abstract: “Cardiovascular disease (CVD) is the leading cause of premature death and disability worldwide, with both genetic and environmental determinants. The most common cardiovascular disease is coronary heart disease (CHD), including coronary atherosclerosis and myocardial infarction, among others. While genome-wide association studies (GWAS) have identified multiple genetic loci associated with cardiovascular diseases, exact genes driving these associations remain mostly uncovered.”
13
Han R, Yu L, Zhao C, Li Y, Ma Y, Zhai Y, Qian Z, Gu Y, Li S.
Inhibition of SerpinB9 to enhance granzyme B-based tumor therapy by using a modified biomimetic nanoplatform with a cascade strategy.
Biomaterials. 2022 Aug 6;121723. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35963816
14
Vilchinskaya N, Altaeva E, Lomonosova Y.
Gaining insight into the role of FoxO1 in the progression of disuse-induced skeletal muscle atrophy.
Adv Biol Regul. 2022 Jul 31;85:100903.
https://pubmed.ncbi.nlm.nih.gov/35947892
Note: Hindlimb unloading results.
15
Berli M, Franco F, Di Paolo J, Zioupos P, Borau C.
The interplay between BMU activity linked to mechanical stress, specific surface and inhibitory theory dictate bone mass distribution: Predictions from a 3D computational model.
Comput Biol Med. 2022 Sep;148:105898.
https://pubmed.ncbi.nlm.nih.gov/35964467
16
Pelusi L, Mandatori D, Di Pietrantonio N, Del Pizzo F, Di Tomo P, Di Pietro N, Buda R, Genovese S, Epifano F, Pandolfi A, Fiorito S, Pipino C.Estrogen receptor 1 (ESR1) and the Wnt/β-catenin pathway mediate the effect of the coumarin derivative umbelliferon on bone mineralization.
Nutrients. 2022 Aug 5;14(15):3209.
https://pubmed.ncbi.nlm.nih.gov/35956385
Note: This article is part of Section “Phytochemicals and Human Health” (https://www.mdpi.com/journal/nutrients/sections/Phytochemicals_Human_Health) and may be obtained online without charge.
17
Nardon M, Pascucci F, Cesari P, Bertucco M, Latash ML.
Synergies stabilizing vertical posture in spaces of control variables.
Neuroscience. 2022 Aug 8. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35952997
Note: From the abstract: “In this study, we address the question: Can the central nervous system stabilize vertical posture in the abundant space of neural commands? We assume that the control of vertical posture is associated with setting spatial referent coordinates (RC) for the involved muscle groups, which translates into two basic commands, reciprocal and co-activation. We explored whether the two commands co-varied across trials to stabilize the initial postural state.”
https://news.google.com/__i/rss/rd/articles/CBMiggFodHRwczovL3NwYWNlcmVmLmNvbS9zcGFjZS1zdGF0aW9ucy9uYXNhLXNwYWNlbGluZS1jdXJyZW50LWF3YXJlbmVzcy1saXN0LTEwMTMtMTktYXVndXN0LTIwMjItc3BhY2UtbGlmZS1zY2llbmNlLXJlc2VhcmNoLXJlc3VsdHMv0gEA?oc=5
2022-08-19 19:21:11Z
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